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Faded yellow around pupil8/16/2023 Intraocular (uveal) melanoma symptoms, tests, prognosis, and stages (PDQ).Centers for Disease Control and Prevention. Initial management of uveal and conjunctival melanomas. In: Kanski's Clinical Ophthalmology: A Systematic Approach. Intraocular (uveal) melanoma treatment (PDQ).Fort Washington, Pa.: National Comprehensive Cancer Network. Eye melanoma can spread outside of the eye and to distant areas of the body, including the liver, lungs and bones. Eye melanoma that spreads beyond the eye.Very advanced eye melanomas can cause complete vision loss. You may have difficulty seeing in the center of your vision or on the side. Small eye melanomas can cause some vision loss if they occur in critical parts of the eye. Large eye melanomas often cause vision loss in the affected eye and can cause complications, such as retinal detachment, that also cause vision loss. Signs and symptoms of glaucoma may include eye pain and redness, as well as blurry vision. A growing eye melanoma may cause glaucoma. Increasing pressure within the eye (glaucoma).Certain genes passed from parents to children may increase the risk of eye melanoma.Ĭomplications of eye melanoma may include: There's some evidence that exposure to UV light, such as light from the sun or from tanning beds, may increase the risk of eye melanoma. The role of ultraviolet exposure in eye melanoma is unclear. In addition, people with abnormal skin pigmentation involving the eyelids and adjacent tissues and increased pigmentation on their uvea - known as ocular melanocytosis - also have an increased risk of developing eye melanoma. A condition called dysplastic nevus syndrome, which causes abnormal moles, may increase your risk of developing melanoma on your skin and in your eye. The risk of eye melanoma increases with age.Ĭertain inherited skin disorders. White people have a greater risk of eye melanoma than do people of other races. People with blue eyes or green eyes have a greater risk of melanoma of the eye. Risk factors for primary melanoma of the eye include: The ciliary body, which is in the front of the uvea and secretes the transparent liquid (aqueous humor) into the eye.Įye melanoma can also occur on the outermost layer on the front of the eye (conjunctiva), in the socket that surrounds the eyeball and on the eyelid, though these types of eye melanoma are very rare.The choroid layer, which is the layer of blood vessels and connective tissue between the sclera and the retina at the back of the uvea. The iris, which is the colored part in the front of the eye.The uvea has three parts and each can be affected by eye melanoma: Where eye melanoma occursĮye melanoma most commonly develops in the cells of the middle layer of your eye (uvea). The mutated cells accumulate in the eye and form an eye melanoma. The DNA errors tell the cells to grow and multiply out of control, so the mutated cells go on living when they would normally die. Doctors know that eye melanoma occurs when errors develop in the DNA of healthy eye cells.
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